(S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one

Base Information

Chemical Name:(S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one
CAS No.:885118-10-5
Molecular Formula:C₃₁H₃₄O₈
Molecular Weight:534.606
Hs Code.:

Synonyms:(S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one

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Chemical Property of (S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one

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Technology Process of (S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one

There total 6 articles about (S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 885118-16-1
C₁₁H₁₇BO₇

: 885117-99-7
trifluoro-methanesulfonic acid 2-[2-(4-benzyloxy-phenyl)-ethyl]-6-oxo-3,6-dihydro-2H-pyran-4-yl ester

: 885118-10-5
(S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one

Guidance literature:: With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 3h; Heating;
DOI:10.1016/j.tetlet.2006.01.159

Reference yield:

: 885118-01-4
(S)-6-[(4-benzyloxy)phenethyl]-5,6-dihydropyran-2-one

: 885118-10-5
(S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂O₂; aq. NaOH / ethanol / 2 h / 0 °C

1.2: PPTS / toluene / 2 h / Heating

1.3: Ph₂Se₂; NaBH₄ / ethanol / 2 h / 0 °C

2.1: 62 percent / PCC / CH₂Cl₂ / 12 h / 0 - 20 °C

3.1: 74 percent / NEt₃ / CH₂Cl₂ / 0.5 h / -78 °C

4.1: 98 percent / aq. K₂CO₃ / PdCl₂(PPh₃)2 / tetrahydrofuran / 3 h / Heating

With sodium hydroxide; dihydrogen peroxide; potassium carbonate; triethylamine; pyridinium chlorochromate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; 4.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2006.01.159

Reference yield:

: 885118-14-9
2-bromo-5-methoxy-1,3-bis(methoxymethoxy)benzene

: 885118-10-5
(S)-6-[2-(4-Benzyloxy-phenyl)-ethyl]-4-(4-methoxy-2,6-bis-methoxymethoxy-phenyl)-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / n-BuLi; B(OMe)3 / 5 h / -78 - 20 °C

2: 98 percent / aq. K₂CO₃ / PdCl₂(PPh₃)2 / tetrahydrofuran / 3 h / Heating

With n-butyllithium; Trimethyl borate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 2: Suzuki coupling;
DOI:10.1016/j.tetlet.2006.01.159