3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester
• CAS No.: 950763-37-8
• Molecular Formula: C₂₆H₂₆N₂O₃
• Molecular Weight: 414.504
• Mol file: 950763-37-8.mol

Synonyms:3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester

Chemical Property of 3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester

There total 3 articles about 3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

methyl 3-formyl-1-(4-methoxybenzyl)-1H-indole-6-carboxylate (950763-33-4) + benzylamine (100-46-9) → 3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester (950763-37-8)

Guidance literature:

methyl 3-formyl-1-(4-methoxybenzyl)-1H-indole-6-carboxylate; benzylamine; With magnesium sulfate; acetic acid; In methanol; at 20 ℃; for 24h;

With sodium tetrahydroborate; In methanol; for 2h;

Reference yield:

methyl 3-formyl-6-indolecarboxylate (133831-28-4) → 3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester (950763-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: magnesium sulfate; acetic acid / methanol / 24 h / 20 °C

2.2: 2 h

With magnesium sulfate; potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 3-(N-benzylamino)methylindole-1-(4-methoxybenzyl)-6-carboxylic acid methyl ester (950763-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: magnesium sulfate; acetic acid / methanol / 24 h / 20 °C

2.2: 2 h

With magnesium sulfate; potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

methyl 3-formyl-1-(4-methoxybenzyl)-1H-indole-6-carboxylate

benzylamine

p-methoxybenzyl chloride

methyl 3-formyl-6-indolecarboxylate

Downstream raw materials:

3-(N-benzylaminomethyl)-1-(4-methoxybenzyl)-1H-indole-6-carboxylic acid hydroxyamide