C₁₄H₁₈O₃

Base Information

• Chemical Name: C₁₄H₁₈O₃
• CAS No.: 142093-49-0
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 142093-49-0.mol

Synonyms:C₁₄H₁₈O₃

Chemical Property of C₁₄H₁₈O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₈O₃

There total 1 articles about C₁₄H₁₈O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C14H16O3 (1224588-21-9) → C14H18O3 (142093-49-0)

Guidance literature:

With sodium tetrahydroborate; nickel (II) chloride hexahydrate; boric acid; In tetrahydrofuran; water; at 0 ℃; for 0.666667h; diastereoselective reaction;

DOI:10.1016/j.tetlet.2010.01.120

Reference yield:

C14H18O3 (142093-49-0) → (4R,6S)-7-(benzyloxy)-4-methyl-2-methylideneheptane-1,6-diol

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / 48 h

2.1: pyridinium p-toluenesulfonate / dichloromethane / 4 h / Reflux

3.1: titanium(IV) isopropylate / tetrahydrofuran / 16 h

4.1: triethylamine / diethyl ether / 2 h / 0 °C

5.1: magnesium bromide / chloroform / 4 h / Reflux

6.1: potassium acetate; N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 12 h

6.2: 4 h

With titanium(IV) isopropylate; N-benzyl-N,N,N-triethylammonium chloride; potassium acetate; pyridinium p-toluenesulfonate; triethylamine; magnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1134/S1070428015070052

Reference yield:

C14H18O3 (142093-49-0) → C22H27F3O5

Guidance literature:

Multi-step reaction with 10 steps

1.1: triethylamine / 48 h

2.1: pyridinium p-toluenesulfonate / dichloromethane / 4 h / Reflux

3.1: titanium(IV) isopropylate / tetrahydrofuran / 16 h

4.1: triethylamine / diethyl ether / 2 h / 0 °C

5.1: magnesium bromide / chloroform / 4 h / Reflux

6.1: potassium acetate; N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 12 h

6.2: 4 h

7.1: sodium; ammonia / diethyl ether / 0.33 h / -78 °C

8.1: periodic acid dihydrate / tetrahydrofuran; water / 3 h

9.1: dichloromethane / 24 h / 20 °C

10.1: pyridine / tetrachloromethane / 24 h / 20 °C

With pyridine; titanium(IV) isopropylate; periodic acid dihydrate; N-benzyl-N,N,N-triethylammonium chloride; ammonia; potassium acetate; sodium; pyridinium p-toluenesulfonate; triethylamine; magnesium bromide; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 9.1: |Wittig Olefination;

DOI:10.1134/S1070428015070052

upstream raw materials:

C₁₄H₁₆O₃