(E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid

Base Information

• Chemical Name: (E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid
• CAS No.: 1192144-45-8
• Molecular Formula: C₂₁H₁₇N₃O₄
• Molecular Weight: 375.384

Synonyms:(E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid

Chemical Property of (E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid

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Technology Process of (E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid

There total 1 articles about (E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 3-(benzoylamino)-6-methyl-2-oxo-2H-pyran-5-carboxylate (97497-15-9) + benzamidine monohydrochloride (1670-14-0) → (E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid (1192144-45-8)

Guidance literature:

ethyl 3-(benzoylamino)-6-methyl-2-oxo-2H-pyran-5-carboxylate; benzamidine monohydrochloride; With sodium carbonate; In ethanol; water; at 100 ℃; for 0.75h; Microwave irradiation;

With hydrogenchloride; In water; pH=2;

DOI:10.1016/j.tet.2009.07.072

Reference yield: 92.0%

(E)-2-(benzoylamino)-3-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)propenoic acid (1192144-45-8) → N-(4-methyl-7-oxo-2-phenyl-7H-pyrano[2,3-d]pyrimidin-6-yl)benzamide (1192144-49-2)

Guidance literature:

In ethanol; at 110 ℃; for 2h; Microwave irradiation;

DOI:10.1016/j.tet.2009.07.072

upstream raw materials:

ethyl 3-(benzoylamino)-6-methyl-2-oxo-2H-pyran-5-carboxylate

benzamidine monohydrochloride

Downstream raw materials:

N-(4-methyl-7-oxo-2-phenyl-7H-pyrano[2,3-d]pyrimidin-6-yl)benzamide

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