Technology Process of methyl 3-amino-2,4-dimethoxybenzoate
There total 1 articles about methyl 3-amino-2,4-dimethoxybenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
HATU; DIPEA;
In
N,N-dimethyl-formamide; acetone;
Ar, to a soln. of Fe compd. (DMF) added HATU and DIPEA, stirred for 30 min, a soln. of amine (acetone) added, stirred for 65 h at room temp.; diluted (ethyl acetate), washed (water), dried (Na2SO4), filtred, concd., chromy. (silica gel, hexane/ethyl acetate), co-evapd. with diethyl ether);
DOI:10.1002/ejic.201100497
- Guidance literature:
-
With
diisopropylethylamine; [C5H3N4OC(N(CH3)2)N(CH3)2]PF6;
In
N,N-dimethyl-formamide; acetonitrile;
Schlenk techniques; addn. of HATU and DIPEA to soln. of Fe complex in DMF, stirring for 30 min under N2, addn. of soln. of (MeO)2C6H2(NH2)CO2Me in MeCN, stirring at room temp. (control by thin layer chromy.) for 70 h; concn. under vacuum, addn. of brine, extn. (EtOAc), washing with 0.5 M HCl, water, brine, drying (Na2SO4), filtration, evapn., flash chromy. (silica gel, hexane/EtOAc (1:1));
DOI:10.1021/om100614c
