4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid
• CAS No.: 1152334-07-0
• Molecular Formula: C₁₉H₁₅N₃O₆
• Molecular Weight: 381.345

Synonyms:4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

Chemical Property of 4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

There total 1 articles about 4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4,5-dioxo-2-phenyl-4,5-dihydrofuran-3-carboxylate (134567-92-3) + benzaldehyde 3-nitrophenylhydrazone (20576-92-5) → 4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (1152334-07-0)

Guidance literature:

at 80 - 90 ℃;

DOI:10.1007/s00706-015-1450-7

Reference yield: 88.0%

4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (1152334-07-0) → 1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid (96723-10-3)

Guidance literature:

4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid; With sodium hydroxide; In water; at 100 ℃; for 3h;

With hydrogenchloride; In water;

DOI:10.1016/j.ejmech.2014.03.033

Reference yield: 63.0%

4-(ethoxycarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid (1152334-07-0) → 2-(3-nitrophenyl)-3-phenyl-5,6-dihydro-2H-pyrazolo[3,4-d]pyridazine-4,7-dione (1608107-88-5)

Guidance literature:

With hydrazine; In toluene; at 110 ℃; for 5h;

DOI:10.1016/j.ejmech.2014.03.033

upstream raw materials:

ethyl 4,5-dioxo-2-phenyl-4,5-dihydrofuran-3-carboxylate

benzaldehyde 3-nitrophenylhydrazone

Downstream raw materials:

ethyl 3-(chlorocarbonyl)-1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-4-carboxylate

1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid

1-(3-nitrophenyl)-5-phenyl-1H-pyrazole-3,4-dicarbonyl dichloride

2-(3-nitrophenyl)-3-phenyl-5,6-dihydro-2H-pyrazolo[3,4-d]pyridazine-4,7-dione

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