17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

Base Information

Chemical Name:17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate
CAS No.:586388-06-9
Molecular Formula:C₂₈H₃₁FO₃
Molecular Weight:434.551
Hs Code.:

Synonyms:17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

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Technology Process of 17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

There total 4 articles about 17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1765-93-1
4-fluoroboronic acid

: 91085-40-4
17α,20E-21-iodo-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

: 586388-06-9
17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 12h;
DOI:10.1021/jm0205806

Reference yield: 17.5%

: 1765-93-1
4-fluoroboronic acid

: 91085-40-4
3-acetoxy-(17α,20Z)-21-(iodo)-19-norpregna-1,3,5(10),20-tetraene-17β-ol

: 859233-86-6
3-acetoxy-(17α,20Z)-21-[(4-fluoro)phenyl]-19-norpregna-1,3,5(10),20-tetraene-17β-ol

: 586388-06-9
17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran;
DOI:10.1021/jm040157s

Reference yield:

: 134970-25-5,134970-24-4
3-acetoxy-17α-(Z)-<2-(tri-n-butylstannyl)ethenyl>estra-1,3,5(10)-trien-17β-ol

: 586388-06-9
17α,20E-21-(4-fluorophenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / NIS / CHCl₃; CH₂Cl₂ / 2 h / -78 °C

2: 17.5 percent / tris(dibenzylideneacetone)dipalladium; aq. Na₂CO₃ / tetrahydrofuran

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; sodium carbonate; In tetrahydrofuran; dichloromethane; chloroform; 2: Suzuki coupling;
DOI:10.1021/jm040157s