1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride

Base Information

Chemical Name:1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride
CAS No.:1417409-12-1
Molecular Formula:C₂₁H₂₀ClN₅O
Molecular Weight:393.876
Hs Code.:

Synonyms:1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride

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Chemical Property of 1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride

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Technology Process of 1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride

There total 6 articles about 1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 110-91-8,99108-56-2
morpholine

: 1417411-62-1
C₁₇H₁₁ClN₄O

: 1417409-12-1
1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride

Guidance literature:: morpholine; C₁₇H₁₁ClN₄O; In 1,2-dichloro-ethane; at 80 ℃; for 0.25h; Microwave irradiation;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; Heating;
DOI:10.1016/j.bmcl.2012.11.077

Reference yield:

: 1417409-03-0
1-(2-chlorophenyl)-8-ethenyl-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

: 1417409-12-1
1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; tert-butyl alcohol / 2 h / 20 °C

2.1: 1,2-dichloro-ethane / 0.25 h / 80 °C / Microwave irradiation

2.2: Heating

With sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; 1,2-dichloro-ethane; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2012.11.077

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1417409-12-1
1-(5-butoxy-2-chlorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo-[4,3-a]quinoxaline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 3 h / Dean-Stark; Reflux

1.2: 2 h / 120 °C

1.3: 0.42 h / 160 - 170 °C / Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / toluene / 1 h / 120 °C

3.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; tert-butyl alcohol / 2 h / 20 °C

4.1: 1,2-dichloro-ethane / 0.25 h / 80 °C / Microwave irradiation

4.2: Heating

With sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In 1,4-dioxane; 1,2-dichloro-ethane; toluene; tert-butyl alcohol; 2.1: |Stille Cross Coupling;
DOI:10.1016/j.bmcl.2012.11.077