(1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

Base Information

Chemical Name:(1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]
CAS No.:350486-15-6
Molecular Formula:C₄₈H₇₈O₆SSi₂
Molecular Weight:839.381
Hs Code.:

(1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

Synonyms:(1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

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Chemical Property of (1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

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Technology Process of (1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

There total 7 articles about (1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 350486-14-5
(1S,2R,5S)-2-[(2'R,5'Z)-5'-(2''-Bromoethylidene)-tetrahydropyran-2'-yl]-1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane

: 334972-61-1
(1S,2R,5R)-2-[(2'R,5'Z)-5'-(2''-Phenylsulfonylethylidene)-tetrahydropyran-2'-yl]-1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane

: 350486-15-6
(1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

Guidance literature:: (1S,2R,5R)-2-[(2'R,5'Z)-5'-(2''-Phenylsulfonylethylidene)-tetrahydropyran-2'-yl]-1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane; With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;

(1S,2R,5S)-2-[(2'R,5'Z)-5'-(2''-Bromoethylidene)-tetrahydropyran-2'-yl]-1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane; In tetrahydrofuran; toluene; at -78 ℃; for 0.333333h; Further stages.;
DOI:10.1039/b100777g

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 350486-15-6
(1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / dimethylformamide / 16 h / 20 °C

2.1: 18-crown-6; KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

2.2: 78 percent / tetrahydrofuran; toluene / 0.33 h / -78 °C

With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b100777g

Reference yield:

: Methyl 2-{(R)-2'-[(1''S,2''R,5''S)-1''-(tert-Butyldimethylsilyloxy)-5''-(1-methylethenyl)-2'-cyclopentyl]tetrahydropyran-5'-ylidene}acetate

: 350486-15-6
(1S,1'S,2R,2'R,5R,5'S)-2,2'-{5,5'-[(R,S)-2-Phenylsulfonylbutane-1,4-diylidene]bis[(2R,5Z)-tetrahydropyran-2-yl]}bis[1-(tert-butyldimethylsilyloxy)-5-(1-methylethenyl)cyclopentane]

Guidance literature:: Multi-step reaction with 3 steps

1.1: 54 percent / DIBAL-H / CH₂Cl₂; toluene / 3 h / 0 °C

2.1: LiBr; s-collidine; DMAP / dimethylformamide / 0.17 h / 0 °C

2.2: 64 percent / Ms₂O / dimethylformamide / 24 h / 4 °C

3.1: 18-crown-6; KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

3.2: 78 percent / tetrahydrofuran; toluene / 0.33 h / -78 °C

With 2,4,6-trimethyl-pyridine; dmap; 18-crown-6 ether; potassium hexamethylsilazane; diisobutylaluminium hydride; lithium bromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b100777g