[3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester

Base Information

Chemical Name:[3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester
CAS No.:867067-85-4
Molecular Formula:C₄₁H₅₇N₅O₄
Molecular Weight:683.935
Hs Code.:

Synonyms:[3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester

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Chemical Property of [3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester

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Technology Process of [3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester

There total 7 articles about [3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 867067-84-3
{3,5-bis-[4-(tert-butoxycarbonylamino-methyl)-benzylcarbamoyl]-phenyl}-carbamic acid hexadec-2-enyl ester

: 867067-85-4
[3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 0.5h;
DOI:10.1039/b506177f

Reference yield:

: 867067-81-0
2-allyloxycarbonylamino-isophthalic acid diethyl ester

: 867067-85-4
[3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / Grubbs 1-st generation catalyst / CH₂Cl₂ / 12 h / Heating

2: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 10 h / 20 °C

3: 67 percent / benzotriazole-1-yl-oxy-trispropylidinophosphonium*PF₆; DIEA / dimethylformamide / 12 h / 20 °C

4: 100 percent / HCl / dioxane / 0.5 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b506177f

Reference yield:

: 99-31-0
5-aminoisophthalic acid

: 867067-85-4
[3,5-Bis-(4-aminomethyl-benzylcarbamoyl)-phenyl]-carbamic acid (E)-hexadec-2-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 5 h / Heating

2: 81 percent / pyridine / 0 - 20 °C

3: 40 percent / Grubbs 1-st generation catalyst / CH₂Cl₂ / 12 h / Heating

4: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 10 h / 20 °C

5: 67 percent / benzotriazole-1-yl-oxy-trispropylidinophosphonium*PF₆; DIEA / dimethylformamide / 12 h / 20 °C

6: 100 percent / HCl / dioxane / 0.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; lithium hydroxide; thionyl chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; Grubbs catalyst first generation; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b506177f