3B,11B,21-Trihydroxy-5B-pregnan-20-one

Base Information

• Chemical Name: 3B,11B,21-Trihydroxy-5B-pregnan-20-one
• CAS No.: 27857-26-7
• Molecular Formula: C₂₁H₃₄O₄
• Molecular Weight: 350.499
• Mol file: 27857-26-7.mol

Synonyms:5b-Pregnan-20-one, 3b,11b,21-trihydroxy- (8CI); 3b,11b,21-Trihydroxy-5b-pregnan-20-one; 3b,5b-Tetrahydrocorticosterone

Chemical Property of 3B,11B,21-Trihydroxy-5B-pregnan-20-one

Chemical Property:

• Boiling Point: 509.6±50.0 °C(Predicted)
• PKA: 12.98±0.10(Predicted)
• PSA: 77.76000
• Density: 1.180±0.06 g/cm3(Predicted)
• LogP: 2.53840

Purity/Quality:

99%min ^*data from raw suppliers

3BETA,11BETA,21-TRIHYDROXY-5BETA-PREGNAN-20-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3β,5β-Tetrahydrocorticosterone

Technology Process of 3B,11B,21-Trihydroxy-5B-pregnan-20-one

There total 2 articles about 3B,11B,21-Trihydroxy-5B-pregnan-20-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3α,11β,21-Trihydroxy-5β-pregnan-20-on (68-42-8,516-16-5,600-62-4,600-63-5,14149-83-8,27857-26-7,72075-11-7)

Guidance literature:

3α,21-Dihydroxy-5β-pregnan-11.20-dion-20-aethylenketal, 1)NaBH4 in Me. (RT, 36 h), 2)Δ mit wss.-methanol. H2SO4 (50 Min.);

Reference yield:

5β-dihydrocorticosterone (566-01-8) → 3β.11β.21-trihydroxy-5β-pregnanone-(20) (27857-26-7)

Guidance literature:

With potassium phosphate; rabbit aldose reductase-like protein AKR₁B₁₉; NADP; In methanol; at 37 ℃; pH=7.4; Kinetics; Enzymatic reaction;

DOI:10.1016/j.abb.2012.07.012

upstream raw materials:

5β-dihydrocorticosterone

Refernces