(R)-(+)-1-(4-PYRIDYL)ETHANOL

Base Information

Chemical Name:(R)-(+)-1-(4-PYRIDYL)ETHANOL
CAS No.:27854-88-2
Molecular Formula:C7H9NO
Molecular Weight:123.155
Hs Code.:29333999
European Community (EC) Number:624-355-1
DSSTox Substance ID:DTXSID40472989
Nikkaji Number:J64.128F
Wikidata:Q72504673
Mol file:27854-88-2.mol

Synonyms:4-Pyridinemethanol,a-methyl-, (R)-;4-Pyridinemethanol, a-methyl-, (R)-(+)- (8CI);(1R)-1-(4-Pyridinyl)ethanol;(R)-(+)-a-Methyl-4-pyridinemethanol;(R)-1-(4-Pyridinyl)ethanol;(R)-1-(4-Pyridyl)ethanol;(R)-4-(1-Hydroxyethyl)pyridine;(aR)-a-Methyl-4-pyridinemethanol;(R)-(+)-1-(4-Pyridyl)ethanol;

Suppliers and Price of (R)-(+)-1-(4-PYRIDYL)ETHANOL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(+)-1-(4-Pyridyl)ethanol
100mg
$ 85.00

TCI Chemical
(R)-4-(1-Hydroxyethyl)pyridine
5G
$ 444.00

TCI Chemical
(R)-4-(1-Hydroxyethyl)pyridine
1G
$ 129.00

Strem Chemicals
(R)-(+)-α-Methyl-4-pyridinemethanol, min. 98%
50mg
$ 67.00

Strem Chemicals
(R)-(+)-α-Methyl-4-pyridinemethanol, min. 98%
100mg
$ 107.00

Sigma-Aldrich
(R)-(+)-α-Methyl-4-pyridinemethanol 99%
1g
$ 139.00

Crysdot
(R)-1-(Pyridin-4-yl)ethanol 98%
5g
$ 542.00

Chem-Impex
(R)-(+)-α-Methyl-4-pyridinemethanol,97.5%(Chiralpurity) 97.5%(Chiralpurity)
1G
$ 301.28

Chemenu
(R)-4-(1-Hydroxyethyl)pyridine 98%
5g
$ 511.00

Chemenu
(R)-4-(1-Hydroxyethyl)pyridine 98%
1g
$ 186.00

Total 46 raw suppliers

Chemical Property of (R)-(+)-1-(4-PYRIDYL)ETHANOL

Chemical Property:

Appearance/Colour:White needles
Vapor Pressure:0.021mmHg at 25°C
Melting Point:67-69 °C(lit.)
Refractive Index:1.535
Boiling Point:239.718 °C at 760 mmHg
PKA:13.52±0.20(Predicted)
Flash Point:98.778 °C
PSA：33.12000
Density:1.083 g/cm³
LogP:1.13490
Storage Temp.:2-8°C
Solubility.:soluble in Methanol
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:123.068413911
Heavy Atom Count:9
Complexity:79

Purity/Quality:

99%, ^*data from raw suppliers

(R)-(+)-1-(4-Pyridyl)ethanol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=NC=C1)O
Isomeric SMILES:C[C@H](C1=CC=NC=C1)O
General Description (R)-(+)-1-(4-Pyridyl)ethanol is an optically active pyridyl alcohol that can be efficiently produced through the deracemization of its racemic form using *Catharanthus roseus* cell cultures. This method achieves high yields (100%) and excellent enantiomeric excess (ee) by stereospecifically converting the (S)-enantiomer to the (R)-form. Additionally, (R)-(+)-1-(4-pyridyl)ethanol can also be synthesized via the reduction of 4-acetylpyridine under controlled incubation conditions, demonstrating the versatility of biocatalytic approaches for obtaining enantiopure pyridyl alcohols.

Technology Process of (R)-(+)-1-(4-PYRIDYL)ETHANOL

There total 20 articles about (R)-(+)-1-(4-PYRIDYL)ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 54656-96-1,42732-22-9
(S)-1-(4-pyridyl)ethanol

: 27854-88-2,42732-22-9
(R)-1-(4-pyridinyl)ethanol

Guidance literature:: at 25 ℃; for 48h; biotransformation using Catharanthus roseus cell cultures in precultured B₅ medium;
DOI:10.1016/S0031-9422(98)00241-6

Reference yield: 99.0%

: 1122-54-9
methyl (4-pyridyl) ketone

: 27854-88-2,42732-22-9
(R)-1-(4-pyridinyl)ethanol

Guidance literature:: With bis(1,5-cyclooctadiene)diiridium(I) dichloride; f-ampha; hydrogen; lithium tert-butoxide; In isopropyl alcohol; at 25 - 30 ℃; for 6h; under 15201 Torr; enantioselective reaction; Inert atmosphere; Autoclave;
DOI:10.1021/acs.orglett.6b03862

Reference yield: 96.0%

: 23389-75-5,42732-22-9
rac-1-(pyridin-4-yl)ethanol

: 108-22-5
Isopropenyl acetate

: 54656-96-1,42732-22-9
(S)-1-(4-pyridyl)ethanol

: 27854-88-2,42732-22-9
(R)-1-(4-pyridinyl)ethanol

(R)-1-(pyridin-4-yl)ethyl acetate: 143840-01-1
(R)-1-(pyridin-4-yl)ethyl acetate

Guidance literature:: With Candida antarctica lipase B; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate; In tetrahydrofuran; toluene; at 50 ℃; for 20h;
DOI:10.1021/ja051576x