methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate
CAS No.:1445789-40-1
Molecular Formula:C₃₂H₃₅N₅O₆
Molecular Weight:585.66
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

Suppliers and Price of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

There total 13 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1445789-38-7
methyl 3-(3-carbamoyl-7-chloro-6-propoxyquinolin-4-ylamino)-5-cyclopentylbenzoate

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445789-40-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 7-chloro-4-hydroxy-6-methoxyquinoline-3-carboxylic acid

: 1445789-40-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate; water / 3 h / Reflux

2: ammonium hydroxide / tetrahydrofuran / 0 °C

3: boron tribromide / dichloromethane / 84 h / 40 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C / Sealed tube

5: ethanol / 16 h / Reflux

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 16 h / 80 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; boron tribromide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: C₁₁H₇Cl₂NO₃

: 1445789-40-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-propoxyquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / tetrahydrofuran / 0 °C

2: boron tribromide / dichloromethane / 84 h / 40 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 50 °C / Sealed tube

4: ethanol / 16 h / Reflux

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 16 h / 80 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;