N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide

Base Information

Chemical Name:N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide
CAS No.:892494-75-6
Molecular Formula:C₃₃H₅₂N₂O₃Si
Molecular Weight:552.873
Hs Code.:

Synonyms:N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide

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Chemical Property of N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide

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Technology Process of N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide

There total 4 articles about N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 892494-59-6
6-((2R)-6-{[tert-butyl(dimethyl)silyl]oxy}-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)-hexylamine

: 10328-92-4
N-Methylisatoic anhydride

: 892494-75-6
N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide

Guidance literature:: With dmap; In N,N-dimethyl-formamide; for 0.5h;
DOI:10.1016/j.bmc.2006.01.053

Reference yield:

: 892494-55-2
[(R)-2-(6-azido-hexyl)-2,5,7,8-tetramethylchromen-6-yloxy]-(tert-butyl)dimethylsilane

: 892494-75-6
N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 - 20 °C

2: 92 percent / 4-dimethylaminopyridine / dimethylformamide / 0.5 h

With dmap; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.053

Reference yield:

: 892494-51-8
methanesulfonic acid 6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]-hexyl ester

: 892494-75-6
N-{6-[(R)-6-(tert-butyl-dimethyl-silanyloxy)-2,5,7,8-tetramethyl-chroman-2-yl]hexyl}-2-methylaminobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 105 mg / NaN₃ / dimethylformamide / 1 h / 55 °C

2: 83 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 - 20 °C

3: 92 percent / 4-dimethylaminopyridine / dimethylformamide / 0.5 h

With dmap; lithium aluminium tetrahydride; sodium azide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.053