trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine

Base Information

Chemical Name:trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine
CAS No.:1201688-82-5
Molecular Formula:C₂₀H₁₉N₅
Molecular Weight:329.404
Hs Code.:

Synonyms:trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine

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Chemical Property of trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine

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Technology Process of trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine

There total 6 articles about trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 123511-51-3
1-methyl-4-phenyl-1H-imidazole-2-carbaldehyde

: 1201688-83-6
(5,7-dimethyl-imidazo[1,2-a]pyrimidin-2-ylmethyl)-triphenyl-phosphonium chloride

: 1201688-82-5
trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;

Reference yield:

: 911719-02-3
methyl 1-methyl-4-phenyl-1H-imidazole-2-carboxylate

: 1201688-82-5
trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 - -5 °C / Inert atmosphere

1.2: 0 °C / pH 6

2.1: Dess-Martin periodane / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield:

: 1051941-62-8
2-chloromethyl-5,7-dimethyl-imidazo[1,2-a]pyrimidine hydrochloride

: 1201688-82-5
trans-5,7-Dimethyl-2-[(E)-2-(1-methyl-4-phenyl-1H-imidazol-2-yl)-vinyl]-imidazo[1,2-a]-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,2-dichloro-ethane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,2-dichloro-ethane;