2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate

Base Information

Chemical Name:2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate
CAS No.:1452162-23-0
Molecular Formula:C₁₄H₁₁F₅O₅
Molecular Weight:354.23
Hs Code.:

Synonyms:2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate

Chemical Property:

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Technology Process of 2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate

There total 6 articles about 2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1452162-19-4
2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetic acid

: 23915-07-3
1-(bromomethyl)-2,4-difluorobenzene

: 1452162-23-0
2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.11.040

Reference yield: 85.0%

: 1452162-23-0
2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1452162-17-2
C₁₃H₁₅F₃O₄

: 1452162-23-0
2,4-difluorobenzyl 2-(2-oxo-4-(trifluoromethyl)-1,3-dioxan-4-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 0.5 h / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane; acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2014.11.040