(R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

Base Information

Chemical Name:(R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one
CAS No.:129144-83-8
Molecular Formula:C₂₅H₃₄O₇
Molecular Weight:446.541
Hs Code.:

Synonyms:(R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

There total 13 articles about (R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-{[(1R,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexyl]-hydroxy-methyl}-3-methyl-2,3-dihydro-pyran-4-one

: 129144-83-8
(R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

: 129144-84-9
(S)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

Guidance literature:: Yield given; Swern oxidation;
DOI:10.1016/S0040-4039(00)70688-5

Reference yield:

: 129144-80-5
3-Bromo-5-methyldihydro-2H-pyran-4(3H)-one

: 129144-83-8
(R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Amberlyst-15, 2) t-BuOK, DMSO / 1) benzene, reflux

2: 1) t-BuLi / 1) THF, 0 deg C

3: oxalic acid / H₂O; CH₂Cl₂

4: Swern oxidation

With amberlyst-15; potassium tert-butylate; tert.-butyl lithium; oxalic acid; dimethyl sulfoxide; In dichloromethane; water;
DOI:10.1016/S0040-4039(00)70688-5

Reference yield:

: 131067-76-0,119124-53-7
3-methyl-tetrahydro-pyran-4-one

: 129144-83-8
(R)-6-[(1S,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexanecarbonyl]-3-methyl-2,3-dihydro-pyran-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1) LDA, TMSCl, 2) NBS / 1) THF, -78 deg C, 2) -78 deg C,

2: 1) Amberlyst-15, 2) t-BuOK, DMSO / 1) benzene, reflux

3: 1) t-BuLi / 1) THF, 0 deg C

4: oxalic acid / H₂O; CH₂Cl₂

5: Swern oxidation

With N-Bromosuccinimide; chloro-trimethyl-silane; amberlyst-15; potassium tert-butylate; tert.-butyl lithium; oxalic acid; dimethyl sulfoxide; lithium diisopropyl amide; In dichloromethane; water;
DOI:10.1016/S0040-4039(00)70688-5