(+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

Base Information

Chemical Name:(+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol
CAS No.:205756-29-2
Molecular Formula:C₁₃H₁₀ClF₄NO
Molecular Weight:307.675
Hs Code.:

Synonyms:(+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

Suppliers and Price of (+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

There total 3 articles about (+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6746-94-7
Cyclopropylacetylene

: 205756-28-1
2'-amino-5'-chloro-3'-fluoro-2,2,2-trifluoroacetophenone

: 205756-29-2
(+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

Guidance literature:: Cyclopropylacetylene; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h;

2'-amino-5'-chloro-3'-fluoro-2,2,2-trifluoroacetophenone; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00486-2

Reference yield:

: 57946-56-2
2-fluoro-4-chloroaniline

: 205756-29-2
(+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

Guidance literature:: Multi-step reaction with 4 steps

1.1: TEA / CH₂Cl₂ / 3 h / 0 - 25 °C

2.1: t-BuLi / tetrahydrofuran / 0.08 h / -50 °C

2.2: tetrahydrofuran

3.1: 6 N aq. HCl / 1,2-dimethoxy-ethane / 2 h / Heating

4.1: n-BuLi / tetrahydrofuran / 1 h / 0 °C

4.2: tetrahydrofuran

With hydrogenchloride; n-butyllithium; TEA; tert.-butyl lithium; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1.1: Acylation / 2.1: Metallation / 2.2: Acylation / 3.1: amide cleavage / 4.1: Metallation / 4.2: Addition;
DOI:10.1016/S0960-894X(99)00486-2

Reference yield:

: 205756-27-0
2'-(trimethylacetamido)-5'-chloro-3'-fluoro-2,2,2-trifluoroacetophenone

: 205756-29-2
(+/-)-2-amino-5-chloro-3-fluoro-α-(cyclopropylethynyl)-α-(trifluoromethyl)benzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 6 N aq. HCl / 1,2-dimethoxy-ethane / 2 h / Heating

2.1: n-BuLi / tetrahydrofuran / 1 h / 0 °C

2.2: tetrahydrofuran

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; 1,2-dimethoxyethane; 1.1: amide cleavage / 2.1: Metallation / 2.2: Addition;
DOI:10.1016/S0960-894X(99)00486-2