5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide

Base Information

Chemical Name:5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide
CAS No.:1599475-02-1
Molecular Formula:C₁₈H₁₁F₃N₄OS₂
Molecular Weight:420.439
Hs Code.:

Synonyms:5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide

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Chemical Property of 5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide

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Technology Process of 5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide

There total 4 articles about 5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1345118-93-5
1-Methyl-3-(1,3-thiazol-2-yl)pyrazol-5-yl boronic acid

: 1599475-24-7
C₁₁H₅BrF₃NOS

: 1599475-02-1
5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide

Guidance literature:: With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; acetonitrile; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 648408-55-3
C₇H₇N₃S

: 1599475-02-1
5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C

1.2: -78 - 20 °C

1.3: 0.5 h

2.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 166196-73-2,942223-95-2
2-(1H-pyrazol-3-yl)-1,3-thiazole

: 1599475-02-1
5-(1-methyl-3-(thiazol-2-yl)-1H-pyrazol-5-yl)-N-(2,4,6-trifluorophenyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h

1.2: 18 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C

2.2: -78 - 20 °C

2.3: 0.5 h

3.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With potassium phosphate; n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydride; In tetrahydrofuran; 1,4-dioxane; acetonitrile;