2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Base Information

Chemical Name:2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide
CAS No.:1215009-50-9
Molecular Formula:C₂₁H₁₈Cl₂N₄O₂S
Molecular Weight:461.372
Hs Code.:

Synonyms:2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

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Chemical Property of 2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

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Technology Process of 2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

There total 5 articles about 2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1215009-29-2
4-bromo-2,6-dichloro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide

: 371766-08-4
isoquinoline 5-boronic acid

: 1215009-50-9
2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 110 ℃; for 1h; Microwave irradiation;
DOI:10.1021/jm201091t

Reference yield:

: 28466-21-9
1,3,5-trimethyl-1H-pyrazol-4-amine

: 1215009-50-9
2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 1 h / 110 °C / Microwave irradiation

With pyridine; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm201091t

Reference yield:

: 351003-54-8
4-bromo-2,6-dichlorobenzenesulfonyl chloride

: 1215009-50-9
2,6-dichloro-4-(isoquinolin-5-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 °C

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 1 h / 110 °C / Microwave irradiation

With pyridine; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm201091t