3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate

Base Information

Chemical Name:3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate
CAS No.:1402933-83-8
Molecular Formula:C₂₇H₄₁NO₅S
Molecular Weight:491.692
Hs Code.:

Synonyms:3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate

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Chemical Property of 3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of 3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate

There total 4 articles about 3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1402933-73-6
tert-butyl (3,5-dimethyladamantan-1-yl)(3-hydroxypropyl)carbamate

: 98-59-9
p-toluenesulfonyl chloride

: 1402933-83-8
3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 3.5h; Inert atmosphere;
DOI:10.1021/jm3009458

Reference yield:

: 41100-52-1
memantine hydrochloride

: 1402933-83-8
3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; zinc / 1,4-dioxane; water / 2 h / 30 °C

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

3: sodium carbonate / water; tetrahydrofuran / 20 °C

4: triethylamine; dmap / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium carbonate; potassium carbonate; acetic acid; triethylamine; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3009458

Reference yield:

: 41100-49-6
MRZ-2169

: 1402933-83-8
3-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)propyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

2: sodium carbonate / water; tetrahydrofuran / 20 °C

3: triethylamine; dmap / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm3009458