POLY-DL-TRYPTOPHAN

Base Information

• Chemical Name: POLY-DL-TRYPTOPHAN
• CAS No.: 27732-43-0
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.228
• Mol file: 27732-43-0.mol

Synonyms:DL-Tryptophan,homopolymer; Tryptophan, DL-, peptides (8CI); Poly-DL-tryptophan

Chemical Property of POLY-DL-TRYPTOPHAN

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of POLY-DL-TRYPTOPHAN

There total 259 articles about POLY-DL-TRYPTOPHAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

DL-γ-glutamaldehydic acid dimethyl acetal (70380-01-7) + phenylhydrazine hydrochloride (59-88-1) → Trp (54-12-6,27732-43-0,80206-30-0,27813-82-7)

Guidance literature:

With sulfuric acid; In water; for 1h; Heating;

DOI:10.1246/bcsj.62.961

Reference yield: 70.0%

rac-3-(1H-indol-3-yl)-2-(benzoylamino)propionic acid methyl ester (104331-05-7) → Trp (54-12-6,27732-43-0,80206-30-0,27813-82-7)

Guidance literature:

In potassium hydroxide; hydrolysis;

DOI:10.1016/S0040-4039(00)81629-9

Reference yield:

N-{(4-{methyl[(4-nitrophenoxy)carbonyl]amino}benzyloxy)carbonyl}-L-tryptophan (402943-23-1) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + carbon dioxide (124-38-9,18923-20-1) + L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) + (4-(methylamino)phenyl)methanol (181819-75-0)

Guidance literature:

With abzyme ST₅₁; water; In dimethyl sulfoxide; at 25 ℃; pH=9.0; Further Variations:; time dependence; Enzyme kinetics;

DOI:10.1039/b103971g

upstream raw materials:

α-(hydroxyimino)-β-(indol-3-yl)propionic acid

5-(3-indolylmethylene)hydantoin

formylamino-indol-3-ylmethyl-malonic acid

acetylamino-indol-3-ylmethyl-malonic acid

Downstream raw materials:

1-benzyl-β-carboline

1-ethyl-9H-β-carboline

3H-indole

1-(3-Indolyl)-2-acetamido-3-butanon

Refernces

• 1、 Gebert,Wieland,Boehringer. "The composition of amanin and phallisin". . p. 227 - 237. Retrieved 1967.
• 2、 Giessen, Tobias W.,Von Tesmar, Alexander M.,Marahiel, Mohamed A.. "A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines". . p. 4274 - 4283. Retrieved 2013.
• 3、 Murakami,Kikuchi,Hisaeda,Nakamura,Kitazaki,Kaya. "Functionalized bilayer membranes as artificial tryptophan synthase. Characterization of catalytic efficiency, substrate specificity, and reaction selectivity". . p. 2339 - 2345. Retrieved 1990.
• 4、 Echevarria Gorostidi, Gerardo R.,Santos, Jose G.,Basagoitia, Andrea,Castillo, Marta,Garcia Blanco, Francisco. "Influence of the polarity of the medium on the catalysis of formation, rate of hydrolysis and stability of the Schiff bases formed by pyridoxal 5′-phosphate with L-tryptophan". . p. 335 - 340. Retrieved 2003.
• 5、 Korzycka, Karolina A.,Bennett, Philip M.,Cueto-Diaz, Eduardo Jose,Wicks, Geoffrey,Drobizhev, Mikhail,Blanchard-Desce, Mireille,Rebane, Aleksander,Anderson, Harry L.. "Two-photon sensitive protecting groups operating via intramolecular electron transfer: Uncaging of GABA and tryptophan". . p. 2419 - 2426. Retrieved 2015.
• 6、 Murakami, Yukito,Hisaeda, Yoshio,Miyajima, Tetsuya,Sakata, Hiroyuki,Kikuchi, Jun-ichi. "Enantioselective β-Replacement Reaction Mediated by an Artificial Enzyme Composed of a Hydrophobic Vitamin B6, Chiral Bilayer-forming Lipids, and Copper(II) Ions". . p. 645 - 648. Retrieved 1993.
• 7、 Echevarria Gorostidi, Gerardo R.,Santos, Jose G.,Basagoitia, Andrea,Garcia Blanco, Francisco. "Determination of the rates of formation and hydrolysis of the schiff bases formed by pyridoxal 5′-phosphate with L-tryptophan and its methyl and n-butyl esters". . p. 2471 - 2476. Retrieved 2002.
• 8、 Kawasaki,Yokota,Tomita. "Enzymatic synthesis of l-tryptophan by Enterobacter aerogenes tryptophanase highly expressed in Escherichia coli, and some properties of the purified enzyme". . p. 1938 - 1943. Retrieved 1995.
• 9、 Jiang, Hong,Yang, Kuiwei,Zhao, Xiangxiang,Zhang, Wenqiang,Liu, Yan,Jiang, Jianwen,Cui, Yong. "Highly Stable Zr(IV)-Based Metal-Organic Frameworks for Chiral Separation in Reversed-Phase Liquid Chromatography". supporting information. p. 390 - 398. Retrieved 2021/01/13.
• 10、 Bunn, Brittney M,Xu, Mizhi,Webb, Chase M,Viswanathan, Rajesh. "Biocatalysts from cyanobacterial hapalindole pathway afford antivirulent isonitriles against MRSA". . . Retrieved 2021/04/26.