2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid

Base Information

Chemical Name:2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid
CAS No.:1374777-53-3
Molecular Formula:C₂₅H₁₈Cl₂N₂O₅S
Molecular Weight:529.4
Hs Code.:

Synonyms:2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid

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Chemical Property of 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid

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Technology Process of 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid

There total 5 articles about 2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1374779-29-9
C₂₉H₂₆Cl₂N₂O₅S

: 1374777-53-3
2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1108745-71-6
2-nitro-terephthalic acid 1-tert-butyl ester 4-methyl ester

: 1374777-53-3
2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 h

2: tetrahydrofuran / 14 h / Reflux

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 5 - 10 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1374779-26-6
t-butyl 2-amino-4-methoxycarbonyl benzoate

: 1374777-53-3
2-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(N-4-chlorophenyl-N-(2-hydroxyethyl)carbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 14 h / Reflux

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 5 - 10 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;