TRT-CYS(TRT)-OH

Base Information

• Chemical Name: TRT-CYS(TRT)-OH
• CAS No.: 27686-50-6
• Molecular Formula: C41H35 N O2 S
• Molecular Weight: 605.79
• Hs Code.: 2930909090
• Mol file: 27686-50-6.mol

Synonyms:Alanine,N-trityl-3-(tritylthio)-, L- (8CI); NSC 275643

Chemical Property of TRT-CYS(TRT)-OH

Chemical Property:

• PSA: 74.63000
• LogP: 9.13750
• Storage Temp.: -15°C

Purity/Quality:

97% ^*data from raw suppliers

Trt-Cys(Trt)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Trt-Cys(Trt)-OH (CAS# 27686-50-6) is a trityl-protected derivative of cysteine and functions as an inhibitor of human mitotic kinesin. As a building block, Trt-Cys(Trt)-OH is used in the synthesis of protein dendrimers for biomedical applications.

Technology Process of TRT-CYS(TRT)-OH

There total 5 articles about TRT-CYS(TRT)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-trityl-L-cysteine (2799-07-7) + trityl chloride (76-83-5) → N,S-Ditrityl-L-Cystein (27686-50-6)

Guidance literature:

With diisopropylamine; In dichloromethane;

Reference yield:

trityl chloride (76-83-5) → N,S-Ditrityl-L-Cystein (27686-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide

2: Et₂NH / CHCl₃; H₂O

With diethylamine; In chloroform; water; N,N-dimethyl-formamide;

DOI:10.1021/ja00879a019

Reference yield:

l-cysteine hydrochloride (52-89-1) + trityl chloride (76-83-5) → N,S-Ditrityl-L-Cystein (27686-50-6)

Guidance literature:

With diethylamine; In diethyl ether;

DOI:10.1021/jm00271a005

upstream raw materials:

L-Cysteine

trityl chloride

l-cysteine hydrochloride

S-trityl-L-cysteine

Downstream raw materials:

(S-trityl-L-cysteinyl)-glycine ethyl ester; hydrochloride

(S)-2-[(R)-2-(Trityl-amino)-3-tritylsulfanyl-propionylamino]-succinamic acid tert-butyl ester

N_.S-Ditrityl-L-cysteinylglycin-p-nitrophenylester

(2S,3S)-2-{(S)-3-(4-Hydroxy-phenyl)-2-[(R)-2-(trityl-amino)-3-tritylsulfanyl-propionylamino]-propionylamino}-3-methyl-pentanoic acid methyl ester

Refernces

• 1、 Barlos, Kleomenis,Mamos, Petros,Papaioannou, Dionysios,Patrianakou, Stella,Sanida, Chariklia,Schaefer, Wolfram. "Application of the Trt and Fmoc Groups for the Protection of Polyfunctional α-Amino Acids". . p. 1025 - 1030. Retrieved 2007/10/02.