(1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate

Base Information

Chemical Name:(1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate
CAS No.:783305-92-0
Molecular Formula:C₃₅H₄₁N₂O₃P
Molecular Weight:568.696
Hs Code.:

Synonyms:(1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate

Chemical Property:

Purity/Quality:

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Technology Process of (1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate

There total 6 articles about (1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16640-68-9
cyanomethylene triphenylphosphorane

: 1026609-73-3
(S)-2-(1-Ethyl-cyclopentylmethoxycarbonylamino)-hexanoic acid

: 783305-92-0
(1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0400799

Reference yield:

: 5453-85-0
ethyl cyclopentanecarboxylate

: 783305-92-0
(1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran; hexane / 0.25 h / -78 - -30 °C

1.2: tetrahydrofuran; hexane / 4 h / -78 - 20 °C

2.1: LAH / diethyl ether; tetrahydrofuran / 6 h / Heating

3.1: tetrahydrofuran; toluene / 20 °C

4.1: Hunig's base / tetrahydrofuran / 20 °C

5.1: aq. LiOH / tetrahydrofuran / 20 °C

6.1: EDCI; DMAP / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; lithium aluminium tetrahydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; 6.1: Wassermann reaction;
DOI:10.1021/jm0400799

Reference yield:

: 783305-71-5
(1-ethylcyclopentyl)methanol

: 783305-92-0
(1-ethylcyclopentyl)methyl (1S)-1-[cyano(triphenylphosphoranylidene)acetyl]pentylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; toluene / 20 °C

2: Hunig's base / tetrahydrofuran / 20 °C

3: aq. LiOH / tetrahydrofuran / 20 °C

4: EDCI; DMAP / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene; 4: Wassermann reaction;
DOI:10.1021/jm0400799