(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone

Base Information

• Chemical Name: (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone
• CAS No.: 1450666-80-4
• Molecular Formula: C₂₂H₂₀F₃N₅O
• Molecular Weight: 427.429
• Mol file: 1450666-80-4.mol

Synonyms:(4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone

Chemical Property of (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone

Chemical Property:

• Boiling Point: 568.7±50.0 °C(Predicted)
• Density: 1.321±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

UCT943 98.70% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone

There total 8 articles about (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.55%

C27H28F3N5O3 (1450666-79-1) → (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone (1450666-80-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.75h; Cooling;

Reference yield:

C20H24BrN5O3 (1450666-78-0) → (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone (1450666-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Inert atmosphere; Reflux

2: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Cooling

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; 1: |Suzuki Coupling;

Reference yield:

C11H9N3O2 (1450666-72-4) → (4-(5-amino-6-(4-(trifluoromethyl)phenyl)pyrazin-2-yl)-phenyl)(piperazin-1-yl)methanone (1450666-80-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / dichloromethane / 2 h / Cooling; Reflux

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: N-Bromosuccinimide / tetrahydrofuran / 0.5 h / 20 °C / Reflux

4.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Inert atmosphere; Reflux

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C / Cooling

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; thionyl chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4.1: |Suzuki Coupling;

upstream raw materials:

C₁₁H₉N₃O₂

C₂₀H₂₅N₅O₃

C₂₀H₂₄BrN₅O₃

C₂₇H₂₈F₃N₅O₃