N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide
CAS No.:306297-12-1
Molecular Formula:C₁₅H₁₈F₃NO₃
Molecular Weight:317.308
Hs Code.:

N<sub>1</sub>-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Synonyms:N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

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Chemical Property of N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

There total 3 articles about N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 306297-11-0
N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide

: 24424-99-5
di-tert-butyl dicarbonate

: 306297-12-1
N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Guidance literature:: N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide; With methyllithium; lithium bromide; In tetrahydrofuran; diethyl ether; at -78 ℃;

With sec.-butyllithium; In tetrahydrofuran; diethyl ether; cyclohexane; at -78 ℃;

di-tert-butyl dicarbonate; In tetrahydrofuran; diethyl ether; cyclohexane; at -78 - 25 ℃;

Reference yield:

: 108-69-0
3,5-dimethylaminoaniline

: 306297-12-1
N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dichlorofluoromethane / 0.25 h / 20 °C / Cooling

2.1: bromine / Dichlorofluoromethane / 3 h / 20 °C / Cooling

3.1: methyllithium / diethyl ether; tetrahydrofuran / -78 °C

3.2: 0.08 h / -78 °C

3.3: 3.5 h / -78 - 20 °C

With methyllithium; bromine; In tetrahydrofuran; diethyl ether; Dichlorofluoromethane;

Reference yield:

: 14818-53-2
N-(3,5-dimethylphenyl)-2,2,2-trifluoroacetamide

: 306297-12-1
N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine / Dichlorofluoromethane / 3 h / 20 °C / Cooling

2.1: methyllithium / diethyl ether; tetrahydrofuran / -78 °C

2.2: 0.08 h / -78 °C

2.3: 3.5 h / -78 - 20 °C

With methyllithium; bromine; In tetrahydrofuran; diethyl ether; Dichlorofluoromethane;