(R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine

Base Information

Chemical Name:(R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine
CAS No.:1400996-94-2
Molecular Formula:C₁₇H₁₉FN₄O
Molecular Weight:314.362
Hs Code.:

Synonyms:(R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine

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Chemical Property of (R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine

Chemical Property:

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Technology Process of (R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine

There total 10 articles about (R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400997-84-3
(R)-tert-butyl 2-(4-(5-cyclopropylpyrimidin-2-ylamino)-2-fluorophenyl)morpholine-4-carboxylate

: 1400996-94-2
(R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine

Guidance literature:: (R)-tert-butyl 2-(4-(5-cyclopropylpyrimidin-2-ylamino)-2-fluorophenyl)morpholine-4-carboxylate; With water; trifluoroacetic acid; In acetonitrile; at 80 ℃; for 16h;

With sodium hydroxide; In water; ethyl acetate; acetonitrile; at 20 ℃;

Reference yield:

: 1400997-77-4
(RS)-1-(4-bromo-2-fluorophenyl)-2-(2-hydroxyethylamino)ethanol

: 1400996-94-2
(R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 0.33 h / 0 - 20 °C

3.1: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 1.5 h / 90 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; sodium acetate / methanol / 50 °C

6.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 120 °C / Inert atmosphere

7.1: trifluoroacetic acid; water / acetonitrile / 16 h / 80 °C

7.2: 20 °C

With hydroxylamine hydrochloride; water; sodium acetate; caesium carbonate; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; isopropyl alcohol; toluene; acetonitrile; 4.1: Buchwald-Hartwig Reaction / 6.1: Buchwald-Hartwig Reaction;

Reference yield:

: 1400997-78-5
(RS)-[2-(4-bromo-2-fluorophenyl)-2-hydroxyethyl]-(2-hydroxyethyl)carbamic acid tertbutyl ester

: 1400996-94-2
(R)-5-cyclopropyl-N-(3-fluoro-4-(morpholin-2-yl)phenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 0.33 h / 0 - 20 °C

2.1: Chiralpak AD / isopropyl alcohol; n-heptane / 13501.4 Torr / Resolution of racemate

3.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 1.5 h / 90 °C / Inert atmosphere

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 50 °C

5.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 120 °C / Inert atmosphere

6.1: trifluoroacetic acid; water / acetonitrile / 16 h / 80 °C

6.2: 20 °C

With hydroxylamine hydrochloride; water; sodium acetate; caesium carbonate; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; isopropyl alcohol; toluene; acetonitrile; 3.1: Buchwald-Hartwig Reaction / 5.1: Buchwald-Hartwig Reaction;