(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

Base Information

Chemical Name:(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt
CAS No.:1548129-04-9
Molecular Formula:C₂₅H₂₁ClF₄N₄O₂S*ClH
Molecular Weight:589.441
Hs Code.:

(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

Synonyms:(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

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Chemical Property of (Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

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Technology Process of (Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

There total 15 articles about (Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

: 1351571-42-0
(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-(3R,4R)-(3-fluoro-1-methylpiperidin-4-yl)-1,3-thiazolidine-2,4-dione

: 1548129-04-9
(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; ethanol; at 20 - 24.6 ℃; for 1.25h;
DOI:10.1021/op400325r

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 1548129-04-9
(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 h / 0 - 20 °C

2: magnesium(II) perchlorate / N,N-dimethyl-formamide / 115 °C

3: ChiralCel-OD / ethanol / Resolution of racemate

4: trifluoroacetic acid / dichloromethane

5: sodium tris(acetoxy)borohydride / dichloromethane

6: hydrogenchloride / ethanol; tetrahydrofuran / 1.25 h / 20 - 24.6 °C

With hydrogenchloride; magnesium(II) perchlorate; sodium tris(acetoxy)borohydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/op400325r

Reference yield:

: 253801-04-6
1H-indazole-5-carbaldehyde

: 1548129-04-9
(Z)-5-((1-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazol-5-yl)methylene)-3-((3R,4R)-3-fluoro-1-methylpiperidin-4-yl)thiazolidine-2,4-dione hydrochloride salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / acetonitrile / 4.08 h / 20 - 34.9 °C

2.1: N,N-dimethyl-formamide / 0.87 h / 20 - 37.8 °C

3.1: hydrogen; water; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon / ethyl acetate; ethanol / 3 h / 20 °C / 258.58 Torr / Inert atmosphere

4.1: toluene / 0.08 h / 20 °C

4.2: 86 h / 111 - 113 °C / Darkness

5.1: hydrogenchloride / ethanol; tetrahydrofuran / 1.25 h / 20 - 24.6 °C

With hydrogenchloride; N-Bromosuccinimide; 5%-palladium/activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/op400325r