5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Base Information

Chemical Name:5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
CAS No.:354581-57-0
Molecular Formula:C₄₀H₃₉N₃O₉
Molecular Weight:705.764
Hs Code.:

5-acetoxymethyl-N<sup>4</sup>-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Synonyms:5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

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Chemical Property of 5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Chemical Property:

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Technology Process of 5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

There total 6 articles about 5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 354581-56-9
5-acetoxymethyl-N⁴-benzoyl-2'-deoxycytidine

: 354581-57-0
5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: With pyridine; for 3h;

Reference yield:

: 40733-26-4
3',5'-O-di(tert-butyldimethylsilyl)thymidine

: 354581-57-0
5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: Br₂ / CCl₄ / 2 h / Heating; irradiation

1.2: 51 percent / dimethylformamide / 1 h

2.1: 85 percent / Et₃N; POCl₃ / acetonitrile / 1 h

3.1: aq. NH₄OH / dioxane / 0.5 h

4.1: 0.85 g / pyridine

5.1: 81 percent / Et₃N*3HF / pyridine

6.1: 76 percent / pyridine / 3 h

With pyridine; ammonium hydroxide; bromine; triethylamine tris(hydrogen fluoride); triethylamine; trichlorophosphate; In 1,4-dioxane; pyridine; tetrachloromethane; acetonitrile;

Reference yield:

: 354581-52-5
5-acetoxymethyl-3',5'-di-O-tert-butyldimethylsilyl-2'-deoxyuridine

: 354581-57-0
5-acetoxymethyl-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N; POCl₃ / acetonitrile / 1 h

2: aq. NH₄OH / dioxane / 0.5 h

3: 0.85 g / pyridine

4: 81 percent / Et₃N*3HF / pyridine

5: 76 percent / pyridine / 3 h

With pyridine; ammonium hydroxide; triethylamine tris(hydrogen fluoride); triethylamine; trichlorophosphate; In 1,4-dioxane; pyridine; acetonitrile;