3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

Base Information

Chemical Name:3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol
CAS No.:1362910-91-5
Molecular Formula:C₁₉H₁₅F₃N₂O₂S
Molecular Weight:392.402
Hs Code.:

Synonyms:3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

Suppliers and Price of 3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

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Chemical Property of 3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

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Technology Process of 3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

There total 5 articles about 3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 6704-31-0
oxetan-3-one

: 1362910-89-1
7-bromo-2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazoline

: 1362910-91-5
3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

Guidance literature:: oxetan-3-one; 7-bromo-2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazoline; With n-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With acetic acid; In tetrahydrofuran;

Reference yield:

: 112253-70-0
2-amino-4-bromobenzamide

: 1362910-91-5
3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilyl polyphosphate / 130 °C

2: Lawessons reagent / toluene / 100 °C

3: potassium carbonate / ethanol / 1.5 h / 20 °C

4: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

With Lawessons reagent; n-butyllithium; potassium carbonate; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 94010-78-3
2,2-difluoro-2-(4-fluorophenyl)acetic acid

: 1362910-91-5
3-(2-(difluoro(4-fluorophenyl)methyl)-4-(methylthio)quinazolin-7-yl)oxetan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilyl polyphosphate / 130 °C

2: Lawessons reagent / toluene / 100 °C

3: potassium carbonate / ethanol / 1.5 h / 20 °C

4: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

With Lawessons reagent; n-butyllithium; potassium carbonate; In tetrahydrofuran; ethanol; toluene;