3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester

Base Information

• Chemical Name: 3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester
• CAS No.: 141854-77-5
• Molecular Formula: C₁₀H₁₄O₄
• Molecular Weight: 198.219

Synonyms:3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester

Chemical Property of 3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester

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Technology Process of 3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester

There total 3 articles about 3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

methyl 2-(bromomethyl)propenoate (4224-69-5) → dimethyl 2,5-dimethylenehexanedioate (31952-35-9) + 4-Hydroxymethyl-3-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester (141854-78-6) + 3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester (141854-77-5)

Guidance literature:

With methyl propargyl alcohol; nickel⁽⁰⁾tetracarbonyl; In acetone; at 30 ℃; for 12h;

DOI:10.1016/S0040-4020(01)92256-2

Reference yield: 39.0%

(3-bromo-propenyl)-phenyl sulfone (36199-65-2) → 4-Hydroxymethyl-3-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester (141854-78-6) + 3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester (141854-77-5) + 1,6,-dibenzensulfonyl-1,4-hexadiene (83600-52-6)

Guidance literature:

With methyl propargyl alcohol; nickel⁽⁰⁾tetracarbonyl; In methanol; acetone; at 30 ℃; for 12h;

DOI:10.1016/S0040-4020(01)92256-2

Reference yield: 39.0%

methyl propargyl alcohol (764-01-2) + methyl 2-(bromomethyl)propenoate (4224-69-5) + tetracarbonylnickel → dimethyl 2,5-dimethylenehexanedioate (31952-35-9) + 4-Hydroxymethyl-3-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester (141854-78-6) + 3-Hydroxymethyl-4-methyl-5-oxo-cyclohex-3-enecarboxylic acid methyl ester (141854-77-5)

Guidance literature:

In acetone; at 30 ℃; for 12h;

DOI:10.1016/S0040-4020(01)92256-2

upstream raw materials:

methyl propargyl alcohol

methyl 2-(bromomethyl)propenoate

(3-bromo-propenyl)-phenyl sulfone

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