[5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

Base Information

• Chemical Name: [5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid
• CAS No.: 1027843-33-9
• Molecular Formula: C₁₆H₁₈ClN₃O₃
• Molecular Weight: 335.79

Synonyms:[5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

Chemical Property of [5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

Chemical Property:

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Technology Process of [5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

There total 2 articles about [5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid benzyl ester (1027892-22-3) → [5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid (1027843-33-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; for 15h;

DOI:10.1021/jm980368v

Reference yield:

Benzyl 2-[(1-cyanoethyl)amino]acetate hydrochloride → [5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid (1027843-33-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / 1,2-dichloro-benzene / 15 h / 100 °C

2: ethyl acetate / 2 h / Heating

3: LiOH / methanol; tetrahydrofuran; H₂O / 15 h

With lithium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; 1,2-dichloro-benzene;

DOI:10.1021/jm980368v

Reference yield:

[5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid (1027843-33-9) → N-(6-amino-2-methyl-pyridin-3-ylmethyl)-2-[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) KOH, 2.) H₂ / 2.) 10 percent Pd/C / 1.) H₂O

2: N-methylmorpholine, HOBT*H₂O, EDC*HCl / dimethylformamide / 1.) from 0 deg C to RT, 2.) RT, 4 h

With 4-methyl-morpholine; potassium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1021/jm980368v

upstream raw materials:

[5-chloro-6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid benzyl ester

Downstream raw materials:

[6-methyl-3-(1-methyl-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-acetic acid

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