(4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Base Information

Chemical Name:(4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride
CAS No.:1352144-37-6
Molecular Formula:C₂₀H₁₇ClF₂N₂*ClH
Molecular Weight:395.279
Hs Code.:

Synonyms:(4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

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Chemical Property of (4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

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Technology Process of (4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

There total 3 articles about (4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.8%

: 1352144-35-4
7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

: 1352144-37-6
(4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

: 1352144-36-5
(4S)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Guidance literature:: 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride; With diethylamine; In methanol; carbon dioxide; Resolution of racemate;

With hydrogenchloride; In ethanol;

Reference yield:

: 418762-89-7
2-chloro-6-(1H-pyrrol-1-yl)benzonitrile

: 1352144-37-6
(4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

: 1352144-36-5
(4S)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 20 °C / Reflux

1.2: 0.5 h / Reflux

2.1: ethanol / 4 h / Reflux

3.1: diethylamine / carbon dioxide; methanol / Resolution of racemate

With dimethylsulfide borane complex; diethylamine; In tetrahydrofuran; methanol; ethanol; carbon dioxide;

Reference yield:

: 418762-90-0
2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt

: 1352144-37-6
(4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

: 1352144-36-5
(4S)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 4 h / Reflux

2: diethylamine / carbon dioxide; methanol / Resolution of racemate

With diethylamine; In methanol; ethanol; carbon dioxide;