2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

Base Information

Chemical Name:2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)
CAS No.:86422-06-2
Molecular Formula:C₂₅H₃₀Cl₂IN₃O₆
Molecular Weight:666.34
Hs Code.:

Synonyms:2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

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Chemical Property of 2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

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Technology Process of 2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

There total 3 articles about 2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 86422-05-1
2-(chloroacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

: 86422-06-2
2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

Guidance literature:: With sodium iodide; In acetone; for 24h; Ambient temperature;
DOI:10.1021/jm00363a023

Reference yield:

: 86422-04-0
2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

: 86422-06-2
2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / CH₂Cl₂ / 0.25 h / Ambient temperature

2: 90 percent / NaI / acetone / 24 h / Ambient temperature

With sodium iodide; In dichloromethane; acetone;
DOI:10.1021/jm00363a023

Reference yield:

: 86422-03-9
2-O-(tert-butyldimethylsilyl)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

: 86422-06-2
2-(iodoacetoxy)-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate)

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

2: 94 percent / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 90 percent / NaI / acetone / 24 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm00363a023