Technology Process of 4'-[(2-ethyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide
There total 8 articles about 4'-[(2-ethyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1.1: hydrogenchloride / water / 2 h / Reflux
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
2.2: 5 h / 0 - 20 °C
3.1: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol; water / 4 h / 20 °C / Inert atmosphere; Reflux
4.1: hydrogenchloride; water / ethanol / 2 h / Reflux
With
hydrogenchloride; water; palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine;
In
propan-1-ol; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.06.011
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere
1.2: 5 h / 0 - 20 °C
2.1: n-butyllithium; boric acid tributyl ester / tetrahydrofuran; toluene / -40 - -20 °C / Inert atmosphere
2.2: -20 - 20 °C
3.1: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol; water / 4 h / 20 °C / Inert atmosphere; Reflux
4.1: hydrogenchloride; water / ethanol / 2 h / Reflux
With
hydrogenchloride; n-butyllithium; boric acid tributyl ester; water; palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine;
In
tetrahydrofuran; propan-1-ol; ethanol; water; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.06.011