Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine

Base Information

Chemical Name:Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine
CAS No.:1349848-61-8
Molecular Formula:C₃₂H₂₄N₄O₂Zn
Molecular Weight:561.958
Hs Code.:

Synonyms:Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine

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Chemical Property of Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine

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Technology Process of Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine

There total 7 articles about Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13-oxophorbine

: 1349848-61-8
Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine

Guidance literature:: With zinc diacetate; In methanol; chloroform; at 20 ℃; for 8h;
DOI:10.1039/c1nj20611g

Reference yield: 70.0%

: 3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13⁽¹⁾-oxophorbine

: 5970-45-6
zinc(II) acetate dihydrate

: 1349848-61-8
zinc(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13⁽¹⁾-oxophorbine

Guidance literature:: In methanol; chloroform; ligand in CHCl3 treated with Zn acetate in MeOH; stirred at room temp. for 8 h; concd.; solid dissolved in CH2Cl2; org. phase washed (satd. aq. NaHCO3, H2O, brine); dried (Na2SO4); concd.; chromd. (alumina, CH2Cl2-MeOH 25:1);
DOI:10.1039/c1nj20611g

Reference yield:

: 892861-52-8
8-bromo-2,3,4,5-tetrahydro-1,3,3-trimethyldipyrrin

: 1349848-61-8
Zn(II)-3-acetyl-17,18-dihydro-18,18-dimethyl-10-phenyl-13'-oxophorbine

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / methanol; dichloromethane / 0.67 h / 20 °C / Inert atmosphere

1.2: 20 h / Reflux

1.3: 2.5 h

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; acetonitrile / 4 h / 83 °C / Inert atmosphere

3.1: hydrogenchloride; water / 0.33 h / 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / dichloromethane; trifluoroacetic acid / 1.5 h / 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / tetrahydrofuran / 4 h / 85 °C / Inert atmosphere

6.1: zinc diacetate / methanol; chloroform / 8 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; zinc diacetate; water; caesium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid; 2.1: Stille coupling;
DOI:10.1039/c1nj20611g