(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

Base Information

Chemical Name:(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline
CAS No.:875014-59-8
Molecular Formula:C₂₈H₃₈N₂O₂
Molecular Weight:434.622
Hs Code.:

Synonyms:(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

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Chemical Property of (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

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Technology Process of (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

There total 4 articles about (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 875014-56-5
(16R,5'S)(8β,9α,14α)-3β-hydroxy-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

: 875014-59-8
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

Guidance literature:: With dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In benzene; at 20 ℃;
DOI:10.1016/j.bmc.2005.08.024

Reference yield:

: 875014-45-2
(8β,9α,14α)-3β-(trifluoroacetoxy)-16(E)-[(p-methoxyphenyl)methylene]-5α-androstan-17-one

: 875014-59-8
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / glacial acetic acid / Heating

2: 55 percent / potassium hydroxide / 2 h / Heating

3: 70 percent / dimethylsulfoxide; trifluoroacetic acid; dicyclohexylcarbodiimide / pyridine / benzene / 20 °C

With potassium hydroxide; acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In benzene; 3: Moffat oxidation;
DOI:10.1016/j.bmc.2005.08.024

Reference yield:

: 875014-53-2
(16R,5'S)(8β,9α,14α)-3β-(trifluoroacetoxy)-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

: 875014-59-8
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-methylpyrazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / potassium hydroxide / 2 h / Heating

2: 70 percent / dimethylsulfoxide; trifluoroacetic acid; dicyclohexylcarbodiimide / pyridine / benzene / 20 °C

With potassium hydroxide; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In benzene; 2: Moffat oxidation;
DOI:10.1016/j.bmc.2005.08.024