Technology Process of C16H13F6NO
There total 5 articles about C16H13F6NO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol;
With
diethylzinc;
In
tetrahydrofuran; n-heptane;
at 0 - 13 ℃;
for 0.5h;
C17H13NO2;
With
L-Tryptophan;
palladium diacetate; 1,3-bis-(diphenylphosphino)propane;
In
tetrahydrofuran; n-heptane;
at 0 - 27 ℃;
for 3.25h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere
2.1: diethylzinc / tetrahydrofuran; hexane / 0.5 h / Cooling with ice; Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
dmap; diethylzinc;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol1030348
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen bromide / dichloromethane / 0.08 h / -20 °C / Inert atmosphere
1.2: 1.5 h / -24 - -20 °C / Inert atmosphere
1.3: -20 - 0 °C / Inert atmosphere
2.1: acetic acid / methanol / 15 - 20 °C / Inert atmosphere
3.1: glucose dehydrogenase 103; alcohol dehydrogenase from Rhodococcus erythropolis; NAD / 20 h / 35 °C / pH 6.5 / aq. phosphate buffer; Inert atmosphere; Enzymatic reaction
4.1: dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere
5.1: diethylzinc / tetrahydrofuran; hexane / 0.5 h / Cooling with ice; Inert atmosphere
5.2: 0 - 20 °C / Inert atmosphere
With
dmap; glucose dehydrogenase 103; alcohol dehydrogenase from Rhodococcus erythropolis; NAD; hydrogen bromide; diethylzinc; acetic acid;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ol1030348
