Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:828247-85-4
Molecular Formula:C₄₇H₅₇N₈O₉P
Molecular Weight:908.992
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 2 articles about Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 828247-72-9
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-cyano-ethoxy)-ethoxy]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-acetamide

: 828247-85-4
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.tetlet.2004.10.151

Reference yield:

: 3386-87-6
1,2-bis-(2-cyanoethoxy)ethane

: 828247-85-4
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogen sulfate

2.1: 96 percent / p-toluenesulfonic acid / dioxane

3.1: tetrabutylammonium fluoride; acetic acid / tetrahydrofuran

3.2: 96 percent / pyridine

4.1: 84 percent / diisopropylethylamine / CH₂Cl₂

With sodium hydrogen sulfate; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.tetlet.2004.10.151

Reference yield: 98.0%

: 2',3'-O-bis-phenoxyacetyluridine

: 828247-85-4
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

: C₆₆H₆₆N₉O₂₀P

Guidance literature:: 2',3'-O-bis-phenoxyacetyluridine; Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(6-acetylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-cyano-ethoxy)-ethoxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester; With 1H-tetrazole; In acetonitrile;

With tert.-butylhydroperoxide;
DOI:10.1016/j.tetlet.2004.10.151