2-Quinoxalinamine, 7-chloro-

Base Information

• Chemical Name: 2-Quinoxalinamine, 7-chloro-
• CAS No.: 2427-70-5
• Molecular Formula: C8H6 Cl N3
• Molecular Weight: 179.609
• Mol file: 2427-70-5.mol

Synonyms:Quinoxaline,2-amino-7-chloro- (6CI,7CI,8CI); 2-Amino-7-chloroquinoxaline

Chemical Property of 2-Quinoxalinamine, 7-chloro-

Chemical Property:

• Melting Point: 194-195 °C
• Boiling Point: 150-160 °C(Press: 10 Torr)
• PKA: 2.86±0.48(Predicted)
• PSA: 51.80000
• Density: 1.445±0.06 g/cm3(Predicted)
• LogP: 2.44660

Purity/Quality:

99%min ^*data from raw suppliers

2-Quinoxalinamine,7-chloro- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Quinoxalinamine, 7-chloro-

There total 2 articles about 2-Quinoxalinamine, 7-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,7-dichloroquinoxaline (59489-31-5) → 7-chloro-quinoxalin-2-ylamine (2427-70-5)

Guidance literature:

With ammonia; In methanol; at 120 ℃; for 16h;

Reference yield:

→ 7-chloro-quinoxalin-2-ylamine (2427-70-5)

Guidance literature:

8-Chlor-alloxazin, 75percentig.H2SO4/200-135grad;

DOI:10.1021/jo01066a047

Reference yield: 33.1%

7-chloro-quinoxalin-2-ylamine (2427-70-5) + 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenol (269410-25-5) → 4-(3-aminoquinoxalin-6-yl)-2,6-dimethylphenol (1250968-57-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;

upstream raw materials:

2,7-dichloroquinoxaline

Downstream raw materials:

4-(3-aminoquinoxalin-6-yl)-2,6-dimethylphenol

Refernces

• 1、 -. "QUINOXALINE DERIVATIVES AND THEIR USE FOR TREATING BENIGN AND MALIGNANT TUMOUR DISORDERS". Page/Page column 24. . Retrieved 2010/11/03.