(S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide

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Chemical Name:(S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide
CAS No.:1447711-12-7
Molecular Formula:C₂₈H₄₄N₂O₅
Molecular Weight:488.668
Hs Code.:

Synonyms:(S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide

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Chemical Property of (S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide

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Technology Process of (S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide

There total 11 articles about (S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1447711-11-6
(S)-dimethyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)succinate

: 1447711-12-7
(S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 25 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 499-76-3
4-hydroxy-3-methylbenzoic acid

: 1447711-12-7
(S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / 6 h / Reflux

2.1: potassium carbonate; potassium iodide / 6 h / Reflux

3.1: diethyl ether / 2 h / 0 - 30 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 2 h / 25 °C

6.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

7.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

8.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

10.1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 25 °C

With sodium tetrahydroborate; sulfuric acid; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 1447711-12-7
(S)-N-(1,4-dihydroxybutan-2-yl)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 25 °C

3.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

4.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

5.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

7.1: sodium tetrahydroborate / methanol / 0.5 h / 0 - 25 °C

With sodium tetrahydroborate; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2013.09.015