Multi-step reaction with 6 steps
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C
1.2: 0.5 h / 20 °C
2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
3.1: sodium iodide / caesium carbonate / N,N-dimethyl-formamide / 70 °C
4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 40 °C
5.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 35 °C
6.1: potassium trimethylsilonate / tetrahydrofuran / 72 h / 20 °C
With
hydrogenchloride; dmap; potassium trimethylsilonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide;
caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;