N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide

Base Information

• Chemical Name: N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide
• CAS No.: 131058-09-8
• Molecular Formula: C₂₃H₁₉N₅O₅S
• Molecular Weight: 477.5

Synonyms:N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide

Chemical Property of N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide

Chemical Property:

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Technology Process of N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide

There total 2 articles about N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

11-chloro-7-nitro-10H-indolo<3,2-b>quinoline (131058-48-5) + 4-methanesulfonamido-2-methoxyaniline hydrochloride (83209-83-0) → N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide (131058-09-8)

Guidance literature:

In 2-ethoxy-ethanol; for 8h; Heating;

DOI:10.1248/cpb.40.1481

Reference yield:

11-chloro-10H-indolo-[3,2-b]quinoline (80271-19-8) → N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide (131058-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / conc. nitric acid / acetic acid / 10 h / Ambient temperature

2: 67 percent / 2-ethoxy-ethanol / 8 h / Heating

With nitric acid; In 2-ethoxy-ethanol; acetic acid;

DOI:10.1248/cpb.40.1481

Reference yield: 72.0%

N-<3-methoxy-4-(7-nitro-10H-indolo<3,2-b>quinolin-11-yl)aminophenyl>methanesulfonamide (131058-09-8) → N-<4-(7-amino-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide (131058-13-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 48h; under 760 Torr;

DOI:10.1248/cpb.40.1481

upstream raw materials:

11-chloro-7-nitro-10H-indolo<3,2-b>quinoline

4-methanesulfonamido-2-methoxyaniline hydrochloride

11-chloro-10H-indolo-[3,2-b]quinoline

Downstream raw materials:

N-<4-(7-amino-10H-indolo<3,2-b>quinolin-11-yl)amino-3-methoxyphenyl>methanesulfonamide

N-<4-<7-(deoxyribofuranosyl)amino-10H-indolo<3,2-b>quinolin-11-yl>amino-3-methoxyphenyl>methanesulfonamide

N-<4-<7-(arabinopyranosyl)amino-10H-indolo<3,2-b>quinolin-11-yl>amino-3-methoxyphenyl>methanesulfonamide

N-<4-<7-(arabinopyranosyl)amino-10H-indolo<3,2-b>quinolin-11-yl>amino-3-methoxyphenyl>methanesulfonamide 2,3,4-O-triacetate

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