2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine

Base Information

Chemical Name:2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine
CAS No.:1357309-33-1
Molecular Formula:C₂₈H₄₁NS₂
Molecular Weight:455.772
Hs Code.:

Synonyms:2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine

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Chemical Property of 2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine

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Technology Process of 2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine

There total 5 articles about 2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1357309-29-5
4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-yne-1-thiol

: 1141-88-4
2-Aminophenyl disulfide

: 1357309-33-1
2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine

Guidance literature:: In dichloromethane; at 20 ℃; for 12.5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.076

Reference yield:

: 1314446-08-6
4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-but-3-yn-1-ol

: 1357309-33-1
2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 20 °C / Inert atmosphere

3: dichloromethane / 12.5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.11.076

Reference yield:

: 1357309-28-4
thioacetic acid S-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyl}ester

: 1357309-33-1
2-{4-[(1R,3aR,7aR)-1-((R)-1,5-dimethylhexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]but-3-ynyldisulfanyl}phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 20 °C / Inert atmosphere

2: dichloromethane / 12.5 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2011.11.076