Technology Process of (8R,10R)-9-benzyl-8-methyl-10-vinyl-1,5-dithia-9-azaspiro[5.5]undecane
There total 5 articles about (8R,10R)-9-benzyl-8-methyl-10-vinyl-1,5-dithia-9-azaspiro[5.5]undecane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
silver hexafluoroantimonate; [AuCl[P(tBu)2(o-biphenyl)]];
In
1,4-dioxane;
at 100 ℃;
for 48h;
stereoselective reaction;
Sealed tube;
Inert atmosphere;
DOI:10.1021/ol103175w
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / dichloromethane / 1.5 h / 0 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
2.2: -78 - 23 °C
3.1: pyrrolidine; samarium diiodide / tetrahydrofuran; water / 0.5 h / 23 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
5.1: silver hexafluoroantimonate; [AuCl[P(tBu)2(o-biphenyl)]] / 1,4-dioxane / 48 h / 100 °C / Sealed tube; Inert atmosphere
With
pyrrolidine; 1H-imidazole; silver hexafluoroantimonate; samarium diiodide; [AuCl[P(tBu)2(o-biphenyl)]]; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol103175w
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyrrolidine; samarium diiodide / tetrahydrofuran; water / 0.5 h / 23 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C
3: silver hexafluoroantimonate; [AuCl[P(tBu)2(o-biphenyl)]] / 1,4-dioxane / 48 h / 100 °C / Sealed tube; Inert atmosphere
With
pyrrolidine; silver hexafluoroantimonate; samarium diiodide; [AuCl[P(tBu)2(o-biphenyl)]]; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ol103175w
