C₃₅H₆₁N₁₃O₇

Base Information

• Chemical Name: C₃₅H₆₁N₁₃O₇
• CAS No.: 102307-14-2
• Molecular Formula: C₃₅H₆₁N₁₃O₇
• Molecular Weight: 775.952
• Mol file: 102307-14-2.mol

Synonyms:C₃₅H₆₁N₁₃O₇

Chemical Property of C₃₅H₆₁N₁₃O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₆₁N₁₃O₇

There total 9 articles about C₃₅H₆₁N₁₃O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-NG-nitroarginyl-NG-nitroarginylisoleucine methyl ester (102307-13-1) → C35H61N13O7 (102307-14-2)

Guidance literature:

With hydrogenchloride; anisole, glacial acetic acid; hydrogen; palladium on activated charcoal; In methanol; for 12h; under 760 Torr;

DOI:10.1021/jm00157a018

Reference yield:

Boc-Arg(NO2)-OH (2188-18-3) → C35H61N13O7 (102307-14-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

2: 89 percent / 4 N HCl / acetic acid / 0.5 h

3: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

4: 86 percent / 4 N HCl, acetic acid anisole, H₂ / 10percent Pd/C / methanol / 12 h / 760 Torr

With hydrogenchloride; anisole, glacial acetic acid; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; acetic acid;

DOI:10.1021/jm00157a018

Reference yield:

methyl L-isoleucinate hydrochloride (18598-74-8) → C35H61N13O7 (102307-14-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / N,N'-dicyclohexylcarbodiimide (DCC), triethylamine (TEA), N-hydroxybenzotriazole (HOBt) / dimethylformamide / 1.) ice bath, 1 h, 2.) 23 deg C, 15 h

2: 4 N HCl / ethyl acetate

3: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

4: 89 percent / 4 N HCl / acetic acid / 0.5 h

5: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

6: 86 percent / 4 N HCl, acetic acid anisole, H₂ / 10percent Pd/C / methanol / 12 h / 760 Torr

With hydrogenchloride; anisole, glacial acetic acid; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00157a018

upstream raw materials:

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

Boc-Arg(NO₂)-OH

methyl L-isoleucinate hydrochloride

(tert-butoxycarbonyl)-N^G-nitroarginylisoleucyl methyl ester