2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone

Base Information

Chemical Name:2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone
CAS No.:1333471-27-4
Molecular Formula:C₂₃H₂₀BrN₃O₄S
Molecular Weight:514.399
Hs Code.:

Synonyms:2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone

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Chemical Property of 2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone

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Technology Process of 2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone

There total 9 articles about 2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1333472-30-2
4-(4-bromo-3,5-dimethoxyphenyl)thiazole

: 1333472-35-7
2-(4-(1H-pyrazol-1-yl)phenyl)-N,2-dimethoxy-N-methylacetamide

: 1333471-27-4
2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone

Guidance literature:: 4-(4-bromo-3,5-dimethoxyphenyl)thiazole; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -20 ℃; for 0.5h; Inert atmosphere;

2-(4-(1H-pyrazol-1-yl)phenyl)-N,2-dimethoxy-N-methylacetamide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1.5h;

Reference yield:

: 31558-40-4
4-bromo-3,5-dimethoxybenzaldehyde

: 1333471-27-4
2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether; tetrahydrofuran / 20 h / -78 - 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 22 h / 20 °C

3.1: bromine / dichloromethane / 0.5 h / 20 °C

4.1: 1,4-dioxane / 20 °C / Inert atmosphere; Reflux

5.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -20 °C / Inert atmosphere

5.2: 1.5 h / -78 °C

With manganese(IV) oxide; bromine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; n-heptane; dichloromethane; ethylbenzene;

Reference yield:

: 1333472-28-8
1-(4-bromo-3,5-dimethoxyphenyl)ethanone

: 1333471-27-4
2-(4-(1H-pyrazol-1-yl)phenyl)-1-(4-(4-bromo-3,5-dimethoxyphenyl)thiazol-2-yl)-2-methoxyethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / dichloromethane / 0.5 h / 20 °C

2.1: 1,4-dioxane / 20 °C / Inert atmosphere; Reflux

3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -20 °C / Inert atmosphere

3.2: 1.5 h / -78 °C

With bromine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; n-heptane; dichloromethane; ethylbenzene;