Technology Process of 3-methyl-1-phenyl-8-benzyl-3,8-diazaspiro<4,5>decanone-2
There total 6 articles about 3-methyl-1-phenyl-8-benzyl-3,8-diazaspiro<4,5>decanone-2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium ethoxide / ethanol / 3 h / Heating
2: 2.) hydrochloric acid / 1.) water, ethanol, reflux, 60 h; 2.) water, reflux, 30 h
3: 1.) sodium ethoxide / 1.) ethanol, 20 min; 2.) ethanol, dimethylformamide, 90 deg C, 3 h
4: 1.) sodium borohydride, 6N hydrochloric acid; 2.) sodium borohydride / ethanol; H2O; CHCl3 / 1.) 0 deg C, 2 h; 2.) 4h
5: 1.) p-toluenesulfonic-acid, calcium sulfate; 2.) sodium cyanoborohydride / 1.) benzene, 60 deg C, 1 h; hexamethylphosphorous triamide, 70 deg C, 1 h
With
hydrogenchloride; calcium sulfate; sodium tetrahydroborate; sodium ethanolate; sodium cyanoborohydride; toluene-4-sulfonic acid;
In
ethanol; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) sodium ethoxide / 1.) ethanol, 20 min; 2.) ethanol, dimethylformamide, 90 deg C, 3 h
2: 1.) sodium borohydride, 6N hydrochloric acid; 2.) sodium borohydride / ethanol; H2O; CHCl3 / 1.) 0 deg C, 2 h; 2.) 4h
3: 1.) p-toluenesulfonic-acid, calcium sulfate; 2.) sodium cyanoborohydride / 1.) benzene, 60 deg C, 1 h; hexamethylphosphorous triamide, 70 deg C, 1 h
With
hydrogenchloride; calcium sulfate; sodium tetrahydroborate; sodium ethanolate; sodium cyanoborohydride; toluene-4-sulfonic acid;
In
ethanol; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) sodium borohydride, 6N hydrochloric acid; 2.) sodium borohydride / ethanol; H2O; CHCl3 / 1.) 0 deg C, 2 h; 2.) 4h
2: 1.) p-toluenesulfonic-acid, calcium sulfate; 2.) sodium cyanoborohydride / 1.) benzene, 60 deg C, 1 h; hexamethylphosphorous triamide, 70 deg C, 1 h
With
hydrogenchloride; calcium sulfate; sodium tetrahydroborate; sodium cyanoborohydride; toluene-4-sulfonic acid;
In
ethanol; chloroform; water;
