3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid

Base Information

Chemical Name:3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid
CAS No.:1376437-11-4
Molecular Formula:C₃₀H₃₆N₂O₅
Molecular Weight:504.626
Hs Code.:

Synonyms:3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid

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Chemical Property of 3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid

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Technology Process of 3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid

There total 7 articles about 3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1376437-10-3
propan-2-yl 2-butyl-3-({4-[1-(trifluoroacetyl)piperidin-4-yl]phenyl}carbonyl)indolizine-7-carboxylate

: 1376437-11-4
3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid

Guidance literature:: propan-2-yl 2-butyl-3-({4-[1-(trifluoroacetyl)piperidin-4-yl]phenyl}carbonyl)indolizine-7-carboxylate; With potassium carbonate; In 1,4-dioxane; methanol; water; at 5 - 25 ℃; for 2h;

di-tert-butyl dicarbonate; With sodium hydroxide; In 1,4-dioxane; water; at 5 - 25 ℃; for 4h;

Reference yield:

: 196204-01-0
4-(piperidin-4-yl)-benzoic acid

: 1376437-11-4
3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 1 h / 5 - 25 °C

2.1: N,N-dimethyl-formamide / 5 h / 70 °C / Sealed tube

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 85 °C

4.1: potassium carbonate / methanol; 1,4-dioxane; water / 2 h / 5 - 25 °C

4.2: 4 h / 5 - 25 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1376436-76-8
2-methyl-4-[(1-methylethoxy)carbonyl]-1-(2-oxohexyl)pyridinium bromide

: 1376437-11-4
3-({4-[1-(tert-butoxycarbonyl)piperidin-4-yl]phenyl}carbonyl)-2-butylindolizine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / isopropyl alcohol / 1.5 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 85 °C

3.1: potassium carbonate / methanol; 1,4-dioxane; water / 2 h / 5 - 25 °C

3.2: 4 h / 5 - 25 °C

With sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; isopropyl alcohol;